Helicopters Otago said if the alleged theft had not been noticed while the helicopter remained on the ground, it could have had fatal consequences for a patient being taken to hospital.
Southern District Police and Helicopters Otago this afternoon issued a joint statement and a "stark warning" to those responsible for the burglary of the helicopter at Taieri Airfield over the weekend.
Drugs from the helicopter’s medical supply stores were among the critical medical equipment and supplies taken, it said.
Helicopters Otago chief executive Graeme Gale said a medical supplies bag was taken from the Queenstown rescue helicopter which had just been used to take a critically ill patient to Dunedin Hospital.
The helicopter and crew were forced to hold over at Taieri Airfield due to bad weather.
"If the helicopter and crew had responded to an incident unaware that the bag had been taken, there could have been fatal consequences."
Acting Area Investigations Manager Detective Sergeant Hayden Smale said this particular theft was concerning on many levels.
"Beyond putting the lives of air ambulance patients at risk by taking these essential medical supplies, some of the drugs stolen pose a significant risk to anyone who may choose to take them recreationally.
"The wrong combination or dosage could potentially be fatal, and we urge extreme caution for anyone who may come into contact with these stolen medical supplies.
"We continue to investigate this matter and will be working hard to identify any available lines of enquiry."
Police would like to hear from anyone who might have information about the burglary, or those involved.
Call police 105 and quote reference number 250112/9460, or share information anonymously through Crime Stoppers on 0800 555 111.