Redmond broke his finger while batting in the second innings in the drawn match with Canterbury in Queenstown last week and Wells took a knock to his troublesome knee.
Both have been ruled out for Otago's first-class match against Central Districts at McLean Park in Napier which starts tomorrow.
The prognosis, particularly for Wells, looks bleak.
''It is not looking particularly promising for the rest of the season,'' Otago coach Mike Hesson responded when asked how bad Wells' injury was.
The promising all-rounder had a breakthrough season with both bat and ball last summer but got injured during a one-day trial match and did not feature in the one-day campaign.
He played in the match against Canterbury last week and took two for 49 from 13 overs in the first innings.
Redmond also played nicely, with a double of 57 and 45.
With six first-class matches still to play, Redmond's chances of making a return are more promising.
''Everyone responds to injuries differently so we will just have to keep monitoring it over the next couple of weeks Hopefully it is not season-threatening.''
''Without making a big score in the one-dayers, he showed some good signs,'' Hesson said.
''It is an opportunity for him to make his first-class debut and I'm looking forward to see how he goes.''
All-rounder Mark Craig will replace Wells in the 12.
Craig is an attacking off-spinner and useful right hand batsman who played six twenty/20 matches for Otago in 2008-09 before he was sidelined with an illness.
He carried the drinks for Otago in its opening Plunket Shield match and, if he gets on the park, he will make his first-class debut alongside Bracewell.
In the only other change, experienced seamer Warren McSkimming makes way for Anthony Bullick, who is returning from a pubic bone stress injury.
McSkimming, who has been saddled with the 12th man's duties more often than he would have liked this summer, is the victim of rotation.
''We've left Warren here [in Dunedin] to make sure he is ready to go for the games at the University Oval.
''With seven four-dayers in eight weeks we've decided to rotate our seamers around, and it is the perfect opportunity to do that.''
Otago (6pts) missed a golden opportunity to cut into Central Districts' (26pts) lead when it fell just two runs short of victory against Canterbury at the Queenstown Events Centre on Sunday.
Canterbury (12pts) secured first innings points and is in second place, with Wellington and Northern Districts on 10 points.
Auckland, the one-day and twenty/20 champion, is in last place with two points from four matches.
