The crash near the intersection of Middleswamp and Guild Rds was reported about 11.45am.
A third person was transported to hospital with critical injuries.
Fire and Emergency New Zealand said two crews from Temuka and Washdyke had to free two people from the vehicle.
St John said it sent five vehicles and medics were treating the injured.
A helicopter had been called to the scene, a St John spokesperson said.
The road has reopened following an examination of the crash scene by the Serious Crash Unit.