A nearby resident said that she heard a loud thud when the incident happened.
Senior Sergeant Mark Crawford of Dunedin Police said a single vehicle, apparently with a steamed up windscreen, collided with a parked vehicle.
Images taken by a bystander showed the windows of the crashed car were steamed up.
A police spokeswoman said they responded to a report of a parked vehicle being hit by a car.
The southbound lane on Kaikorai Valley Rd was closed for a short amount of time, she said.
A spokesman from Fire and Emergency New Zealand said it responded with appliances from the Willowbank and Roslyn Stations.
The two appliances assisted police at the scene, the spokesman said.
A St John spokeswoman said it was notified at 10.20pm.
One ambulance responded and two patients were transported to Dunedin Hospital with minor injuries, the spokeswoman said.
