Two people have been flown to Dunedin Hospital after a crash near Harington Point.
A St John spokesman said one person had moderate injuries and one had minor injuries.
Both were taken to hospital in a rescue helicopter.
A police spokeswoman said they were alerted to the single-car crash at 5.02pm.
The car ended up on its side in Harington Point Rd, near Ellison Rd.
Lookout Point station officer Peter O'Shea said fire crews assisted at the scene and helped the occupants from the vehicle.
The road was closed for a time before the vehicle was recovered, he said.