A spokesman for the 59-year-old rocker says he and his wife of 20 years, model Elaine Mellencamp (nee Irwin), are splitting up.
Publicist Bob Merlis declined to say if the couple had filed for divorce.
Merlis says the Mellencamps "are proud of their 20 years together and are very happy with their accomplishments both as parents and as a family."
He says they will continue to raise their two children in Indiana.
Mellencamp's latest album, "No Better Than This," was released earlier this year.