Laulala, who scored four tries in the first three rounds of the competition, injured his right shoulder in the match against the Hurricanes last weekend and will be replaced by Adam Whitelock.
Fullback Leon MacDonald has also failed a fitness test on the shoulder he injured in the first-round victory over the Chiefs. Coach Todd Blackadder also had to bracket prop Ben Franks (foot injury) with Bronson Murray and halfback Andy Ellis (sprained ankle) with Kahn Fotuali'i when he named his side today.
Tasman wing Blair Cook, 25, will earn his first Crusaders cap on the left flank as a replacement for Kade Poki, who sprained an ankle against the Hurricanes last weekend.
Hamish Gard comes on to the bench as cover for the backs.
