That sees Waisake Naholo come back in on the right wing, while Sio Tomkinson will play on the other wing.
Shannon Frizell returns at blindside flanker, while Alex Ainley comes in to partner Tom Franklin at lock.
Aki Seiuli will start at loosehead prop.
The side is set to play the Sharks on Sunday morning in Durban.
Coach Aaron Mauger said the side was expecting a tough game.
"We know the Sharks recently had a good tour of Australia and New Zealand where they played some great rugby so they will present plenty of threats on Saturday [local time].
"Our guys have really embraced the tour so far and we have enjoyed each other’s company and have worked hard at getting our game to the level it needs to be each week."
Highlanders: Ben Smith (co-captain), Waisake Naholo, Rob Thompson, Tei Walden, Sio Tomkinson, Lima Sopoaga, Aaron Smith, Luke Whitelock, Dillon Hunt, Shannon Frizell, Tom Franklin, Alex Ainley, Tyrel Lomax, Liam Coltman, Aki Seiuli. Reserves: Ash Dixon (cc), Daniel Lienert-Brown, Kalolo Tuiloma, Jackson Hemopo, Elliot Dixon, Kayne Hammington, Josh Ioane, Matt Faddes/Josh McKay.