It was one-way traffic in the second spell as Southern put the foot down to thump University A 70-3 at Bathgate Park.
Replacement winger Harry Uffindell came on in the second spell and used his blistering speed to score three tries and tear the student defence apart.
The Southern win came from a solid pack that dominated the set pieces and also controlled the breakdown.
Props Kees Meeuws and Warren Moffat gave Southern control in the scrums and were also skilled with the pick and go.
Locks Sam Gavigan and Tom Franklin gained a monopoly of ball in the lineout.
Luke Herden was able to break through the midfield and fullback Joe Hill had pace when entering the backline or counter-attacking.
The depleted students were still in the game after 30 minutes when they trailed Southern 12-3 and were attacking just 5m from the Southern line. But the students turned over the ball and it was grabbed by Meeuws, who drove up field with Moffat.
Herden used his strength to get to halfway and the Joe Hill then sped away over the last 50m.
Southern added another try before the break to lead 27-3 at halftime and took full control in the second spell.
- Southern 70 (Harry Uffindell 3, Joe Hill, Greg Zampach, Seb Hill, Andrew Stead, Tom Franklin, Sam Gavigan, Kees Meeuws, Warren Moffat tries; Tony Fenner 6 con, pen), University A 3 (Tom Halse pen). Halftime: Southern 27-3. Referee: Liam Scanlon.