The decision was made by the veteran's sprinter owners Bill and Sandra Duell and trainer Paul Richards, after the horse developed a tendon issue.
The evergreen 9yr-old had been so good to the trio they did not want to risk serious injury by continuing his career.
``He was starting to develop tendon problem. We could have patched him up,'' Richards said.
``If we carried on he would have broken down eventually and we were not going to do that to him.''
Natuzzi signs off his career after winning in each of his seven seasons of racing.
In 48 starts the horse won races from Invercargill to Auckland, and in Melbourne.
The then Wingatui sprinter made a promising start to his career by winning five races including the Southland Guineas, and running second in the White Robe Lodge Handicap.
It was his sixth win that would stamp him as a quality racehorse.
Natuzzi blew the North Island's sprinters away with a dominant win in the Lightning Handicap at Trentham.
The win was one of six races the horse would win at group or listed level.
A year later the horse came back and won the race again, which would soon have him on a plane to Melbourne.
There he scored a win in listed company at Caulfield with regular rider Chris Johnson aboard that Richards regards as his career highlight.
In two more Australian starts the horse ran into a wet track in his next start at Caulfield before running a creditable ninth of 19 in the group 1 Goodwood Handicap in Adelaide.
``He took us to places we would not have got to without him,'' Richards said.
``Winning at Caulfield was definitely a highlight, for me, that and his first Lightning.
``It wasn't their best sprinters, but it was a listed race and taking him over there was pretty special.''
Natuzzi returned home and spelled before heading north to New Zealand Cup week before finding a new home at the opposite end of the country.
The horse accompanied Richards in his shift to set up stables in Auckland in late 2014.
From there, the horse was a regular in the country's top class sprinting races.
Although he claimed his share of group and listed wins he could not quite claim a group 1 scalp with his connections having to settle for five group 1 placings.
Richards described Natuzzi as a pleasure to train.
``He was very good to have around the stable and he was easy enough to train in that he did not take a lot of work once you got him fit.''
``He got better at travelling with the more he did, so he was a very good traveller.''
The only glitch in his armour Natuzzi displayed during his career was a tendency to overrace, especially as a young horse.
``At times he used to beat himself. He was a hard puller. If there was no pace on he wouldn't relax,'' Richards said.
``We changed his training around and used to work him a bit like the trotters.''
``We'd work him behind a couple and not pull him out.''
``And it did help him a bit; he got the hang of it in the finish.''
Natuzzi is chilling out at Richards' stable before embarking on a dressage career.
``He used to do a bit of dressage at Wingatui as part of his training regime and he enjoyed it and he wasn't too bad at it either,'' Richards said.
