The Aucklander beat 18-year-old American Jaye Marie Green 3 and 1 at The Country Club course in Cleveland.
Ko was two up on the 16th and won the par four 17th to go 3 up and take the title.
It was a commanding performance by the New Zealander, she led from the start and at one stage was 4 up.
Ko won the NSW Open in January at age 14 to become the youngest player to win a professional tour event.