Coe said regulations would be drafted soon and the global body, which governs track-and-field and road-running events, would find a test provider with the capacity to conduct the non-invasive cheek swab or dry blood spot analysis tests.
Like other sports, athletics has spent years debating eligibility criteria to compete in women's events, amid questions over biological advantages for transgender athletes and those with differences of sex development (DSD).
World Athletics now bans transgender women who have gone through male puberty from competing in women's events, and requires female DSD athletes whose bodies produce high testosterone levels to lower them in order to be eligible.
A working group found last month that those rules were not tight enough, concluding that athletes who are born male can have advantages over those born female, even if they do not go through male puberty.
A pre-clearance test for the SRY gene was one of several recommendations the group made for revised rules.
"The pre-clearance testing will be for athletes to be able to compete in the female category," Coe told reporters.
"The process is very straightforward, frankly very clear, and it's an important one. We will look for a testing provider, we will work on the timelines, and the tests will only need to be done once in the career life of an athlete."
Coe said he was confident that the new rules would stand up to legal challenges and scrutiny.
"We'll doggedly protect the female category and do whatever it takes to do it."
