Two people have been critically injured in a crash at Thomsons Crossing, just south of Winton.
The crash on State Highway 6, the Winton Lorneville Highway, near Gap Road East, involved two vehicles and was reported at about 5.40pm, police said.
A Hato Hone St John spokesman said three people were airlifted to Dunedin Hospital, two with critical injuries and one with serious injuries.
Another three people were transported by ambulance to Kew Hospital, all in serious conditions.
Three helicopters, one rapid response vehicle, five ambulances and two managers responded to the crash.
A Fire and Emergency NZ spokeswoman said two crews were sent from Winton and one from Kingswell to help at the scene.
She was aware of one person needing to be freed from a vehicle in the crash.
The road was closed and diversions in place.
Motorists were advised to avoid the area and expect delays.
- APL