Emergency services were called to a rural farm track on the station after a vehicle rolled into a ditch and on to its roof, trapping the people inside.
A police spokesman said emergency services attended the single-vehicle crash on a farm track off Timaru Creek Rd, near Lake Hāwea, at 6pm.
Three people were inside the vehicle which crashed.
Two people had critical injuries and one was seriously hurt.
Geoff Ross said his wife and two family friends were involved in the crash.
"Justine and one other occupant of the vehicle suffered critical injuries and were airlifted to Dunedin Hospital; the other occupant suffered moderate injuries and was taken by ambulance also to Dunedin Hospital.
"All three patients are expected to make a full recovery."
The Serious Crash Unit and WorkSafe were both notified.
Mr Ross said the family would like to express their gratitude and appreciation for the Lake Hāwea and Wanaka Volunteer Fire Brigades, Lakes District Air Rescue Trust and Dunedin Hospital staff for their incredible support.
The Rosses bought the 6500ha Lake Hawea Station in April 2018.
