The pharmacy at Owaka becomes a depot this Monday, but some residents are unsure about the changes.
Owaka Plunket member Sandra Grant said she was not sure if people realised "everything" would change on Monday.
"We just want some information."
One of the pharmacy's three owners, Ngaire Taylor, said the depot would be open five days a week, 9.30am to 5.30pm, and prescriptions would be dispensed from Balclutha and delivered twice daily.
The depot would be named Elwyn Bates Catlins Health and Gifts.
Under the five-day service, Owaka people would still have access to goods traditionally stocked by pharmacies, including pharmacy-only medicines, but there would be no pharmacist on the premises to prepare or dispense medicines.