Volunteers have been hard at work compiling the archives from the school, with a massive trove of photo albums, stories, and displays to share.
The event will feature a kapa haka performance on Saturday, alongside the planting of a ceremonial tree and cutting of cake to mark the historical moment.
Later in the night, there will be a dinner and dance at the Mataura Community Centre.
Mataura School principal Susan Dennison said the committee had been hard at work compiling the last 150 years of the school.
"There’s photos, information, we’ve had people bring in their memories, and the Mataura Museum has a lot as well."
Mrs Dennison said there had already been more than 240 registrations, and they were ready to provide a great day for all those who came.
"Our committee has met regularly for the past 12 months, but prior to that there were a lot of discussions.
"Mataura School was the biggest school in the South Island in the 1960s, so there were a huge amount of people who used to go to school here.
"So even though we’re a smaller school now, how do we cater for that, and make sure we provide the opportunity for people to come and reminisce on their school days?"
Mataura School Jubilee Committee member Shona Willis said for those ex-pupils travelling from near and far, the day would provide a chance to take a look back.
"I think there will be so many people who will relish the opportunity to come back to their home town, to reminisce with their friends.
"It’s a chance to reconnect, but also to celebrate the last 150 years," she said.
Mrs Willis said the gathering of history was unlike anything she had seen before.
"Although there have been several jubilees, we’re not sure if there’s been quite as much collecting historical records and photos that’s gone on.
"We know there’s lots of people coming."
