Police said emergency services were called to the crash on State Highway 1, just 500 metres north of the intersection with Titri Rd, at 9.15am.
A reporter at the scene said a north-bound truck and trailer unit was involved and the trailer had overturned.
The other vehicle, a car, had gone over a bank and there was a lot of debris over the road.
A rescue helicopter landed at the scene but left soon after.
A police spokesperson this afternoon confirmed the driver of the car died in the crash.
The road remained closed, with diversions in place, for much of today. Police issued an update at 7.45pm saying the road had reopened.
A police serious crash unit was earlier sent to the scene.
- By John Lewis and ODT Online