Barcelona's Lionel Messi (R) scores his fourth goal past Bayer Leverkusen's goalkeeper Bernd Leno during their Champions League last 16 second leg match at Nou Camp in Barcelona. REUTERS/Albert Gea
The World Player of the Year found the net twice before halftime and three times in the second half at the Nou Camp.
Barcelona won the game 7-1 to reach the last eight 10-2 on aggregate.
Ten players scored five goals in a match in the old European Cup.