Manchester City claimed a vital edge in their Champions League quarter-final tie against Paris St Germain after grabbing two away goals in a scrappy 2-2 first leg draw.
Barcelona's dynamic attacking trio of Neymar, Luis Suarez and Lionel Messi were too strong for Arsenal as all three scored in a 3-1 victory that sent the Spanish side into the Champions League quarter-finals 5-1 on aggregate.
Zlatan Ibrahimovic struck the winner as a clinical Paris St Germain team outclassed Chelsea 2-1 to reach the Champions League quarter-finals.
Manchester United ended their one-year Champions League hiatus in emphatic style when captain Wayne Rooney struck a hat-trick in a 4-0 destruction of Club Bruges that sent the three-time winners through 7-1 on aggregate.
Barcelona were crowned kings of Europe for the fifth time after beating Juventus 3-1 in a superb Champions League final at the Olympic Stadium, capping their magnificent season with a treble of titles.
Cometh the hour cometh the man and Barcelona's Lionel Messi has again stepped up to the mark in sensational fashion.
Manchester City were knocked out of the Champions League by Barcelona to leave the English Premier League without a representative in the last eight of Europe's elite club competition for the second time in three years.
AS Monaco gave Arsenal a lesson in patient, counter-attacking football to win their Champions League last 16 first leg-match 3-1 in London and take a stranglehold on the tie.
Manchester City concluded one of the great Champions League Houdini acts as they qualified for the knockout stages with goals from Samir Nasri and Pablo Zabaleta sinking Roma 2-0 to eliminate the Italians at the Stadio Olimpico.
Chelsea gave a helping hand to a former hero by rounding off the Champions League group stage with a 3-1 victory over Sporting which sent the Portuguese side packing and opened the door for Schalke 04 to reach the last 16.
Real Madrid coach Carlo Ancelotti hailed his "extraordinary" players after they set a Spanish record for consecutive victories of 19 thanks to a 4-0 success at home to Ludogorets in a Champions League Group B encounter.
Typically late heroics from Steven Gerrard could not prevent Liverpool's Champions League challenge ending in failure as FC Basel withstood a late revival to reach the last 16 with a 1-1 draw.
Arsenal midfielder Aaron Ramsey scored a contender for goal of the season when he blasted home a 30-metre volley to help his team cruise past Galatasaray 4-1 to finish second in Group D in the Champions League.
Arsenal held their nerve, their lead and their record of reaching the Champions League knockout stages when they beat Borussia Dortmund 2-0 to reach the last 16 for the 15th season in a row.
Cristiano Ronaldo renewed his personal battle with Lionel Messi by scoring his 71st Champions League goal, putting him three behind the Argentine's newly-set record, in Real Madrid's 1-0 win at FC Basel.
A late header from defender Georgi Terziev earned Ludogorets a 2-2 Champions League draw with an unimpressive Liverpool that left the English side facing a winner-takes-all final match with FC Basel.
There will be plenty of tension in the air in North London this week when out-of-sorts Arsenal face Borussia Dortmund seeking to qualify from the Champions League group stage for the 15th successive season.
Manchester City's lack of fighting spirit was evident when their Champions League dream was on the line against CSKA Moscow this week.
Barcelona forward Lionel Messi equalled the Champions League scoring record of 71 goals when he struck for the second time in the 76th minute of the Group F match at Ajax Amsterdam.
Chelsea stretched their unbeaten start to the season to a club record-equalling 16 games with a 1-1 Champions League draw against Maribor but the 2012 winners were given a mighty scare.