Arnold Robinson told The Associated Press on Thursday the 52-year-old actor was "currently under observation" at the hospital.
Paramedics responded to a 911 call at about 9.30am (local time) on Wednesday at a home in the Sherman Oaks section of Los Angeles and took a patient to a hospital, the city's fire department said.
Public records list the address as Perry's. No reason for the hospitalisation or any details on his condition have been given.
However, celebrity website TMZ said Perry was rushed to hospital after suffering what it described as a "massive stroke."
Perry has also played construction construction-company owner Fred Andrews, father of main character Archie Andrews, for three seasons on Riverdale. The Netflix series gives a dark take on "Archie" comics and has been slated for a fourth.
Born and raised in rural Fredericktown, Ohio, Perry was tapped for heartthrob status along with Jason Priestley on Beverly Hills 90210, which ran from 1990 to 2000.
Perry has had roles in a handful of films, including The Fifth Element, 8 Seconds and American Strays.
He appeared in HBO's prison drama Oz and voiced cartoons including The Incredible Hulk and Mortal Kombat. In recent years he starred in the series Ties That Bind and Body of Proof.
The same day he was hospitalised, Fox TV announced that it would be running a six-episode return of 90210 that features most of the original cast including Jason Priestley, Jennie Garth and Tori Spelling, but Perry was not among those announced.
