Senior Sergeant Anthony Bond, of Dunedin, said police attempted to stop a green Kawasaki motorbike in Gordon Rd, Mosgiel at 6.05pm after complaints from the public.
When signalled to stop, the rider took off at speed and police chose not to follow for safety reasons.
The motorbike rider was then clocked at 160kmh on the Southern Motorway.
When the biker came over the Lookout Point hill, they did a wheelie, Snr Sgt Bond said.
Police were trying to identify the rider and asked the public if they have any information to call 105.