Four fire crews battled a blaze at a house in Lookout Point which was "well alight" on arrival.
A Fire and Emergency New Zealand spokeswoman said they received several calls about a house being on fire in Thomson St about 12.05pm.
Crews from the nearby Lookout Point Fire Station and St Kilda were first to the scene, where the house was described as "well alight", she said.
The fire started in the house but the cause was not yet known, the Fenz spokeswoman said.
A St John spokeswoman said they transferred one person in a moderate condition to Dunedin Hospital.