"It's really exciting. It feels very arty and eclectic here," she said this week.
Ms Macgregor recently arrived in Dunedin from the Court Theatre in Christchurch, to manage the Fortune's artistic and operational activities.
She joined new theatre manager Jeremy Smith, who moved from Sydney in September.
The theatre has not had a permanent artistic director since Martin Howells left in 2002.
Ms Macgregor (41), who has international experience as an actor and director, including stints in the United States, completed a postgraduate diploma in directing at the elite National Institute of Dramatic Art in Sydney.
She was appointed associate artistic director at the Court Theatre in 2009.
A priority in her new position was a commitment to contemporary New Zealand work, she said.
"I'm really looking forward to embracing quality New Zealand plays at the Fortune, and taking it to the regions. We're in a golden age of New Zealand theatre and I want to ensure the New Zealand content reaches at least 50%, including the kids' shows," she said.
"My long-term artistic vision for the theatre encompasses so many things, but consistency of quality will always be at the forefront.
"One exciting element of our 2011 season is that all plays were written in the last decade, so there will be quite a contemporary feel, including a spectacular new Broadway musical which we can't wait to announce.
"We also aim to provide professional development for artists and technicians at the theatre, nourish educational development and provide greater incentives for our audiences, sponsors and supporters."
The Fortune will produce nine plays this season, including the world premiere of The Truth Game, by Otago Daily Times deputy editor Simon Cunliffe, and Roger Hall's latest play, A Short Cut to Happiness.
"It's a real risk putting The Truth Game on during the Rugby World Cup, but I felt it was important that people could see something New Zealand when visiting Dunedin," Ms Macgregor said.
"It's a challenging slot. Some theatres haven't programmed for that time.
"We'll also be supporting the [Dunedin] Fringe Festival and hosting an array of visiting shows," she said.
"My biggest desire is that this year the Fortune productions will bring much joy and pride to Otago and Southland theatre-goers," she said.
The Fortune will launch its full 2011 programme on February 9.
