Museum officials announced Thursday that John will perform during the April 28 benefit at Butler University.
White was diagnosed with AIDS at age 13 after receiving a tainted transfusion of a blood-clotting agent. He died April 8, 1990, at age 18.
He became the public face of AIDS education as he fought to be allowed to attend school. He forged friendships with celebrities including John, who performed at his funeral.
White is featured prominently in the museum's "Power of Children: Making a Difference" exhibit.