Manchester City rediscovered their swagger to beat Chelsea 2-0 and move into the quarter-finals of the FA Cup, Manuel Pellegrini winning the battle of tactical wits against Jose Mourinho.
Alvaro Negredo and Edin Dzeko scored twice each as Premier League high-fliers Manchester City comprehensively quashed second tier Blackburn Rovers' hopes of causing an FA Cup shock with an emphatic 5-0 third-round replay win.
Premier League leaders Arsenal showed their class as they comfortably beat London arch-rivals Tottenham Hotspur 2-0 at the Emirates Stadium to book a place in the FA Cup fourth round.
Wigan Athletic claimed one of the greatest FA Cup final upsets of all time when a 90th minute header from substitute Ben Watson gave them a 1-0 win over highly-fancied Manchester City at Wembley Stadium.
Manchester City reached a second FA Cup final in three seasons after the 2011 winners ended holders Chelsea's hopes of another Wembley triumph with a 2-1 victory in a pulsating semi-final.
Chelsea's love affair with the FA Cup continued when a brilliant goal by Demba Ba gave them a 1-0 win over Manchester United in a sixth-round replay at Stamford Bridge.
Millwall beat fellow second-tier club Blackburn Rovers 1-0 in an FA Cup quarter-final replay on Wednesday to set up a last-four clash at Wembley with Premier League Wigan Athletic.
Holders Chelsea inflicted more pain on Manchester United when they came from two goals down to draw 2-2 in a fluctuating FA Cup quarter-final at Old Trafford.
Manchester City's Argentina striker Carlos Tevez scored a hat-trick two days after he was arrested as they cruised past Barnsley 5-0 to join history makers Wigan Athletic in the FA Cup semi-finals.
Second-half goals from Ramires and Victor Moses have secured FA Cup holders Chelsea a 2-0 fifth round win at second tier Middlesbrough and set up a mouthwatering quarter-final at Manchester United.
Substitute Nani reminded manager Alex Ferguson of his qualities by inspiring Manchester United to a laboured 2-1 home win over Reading in the FA Cup fifth round.
The Premier League's big-hitters have restored some normality to the FA Cup with holders Chelsea crushing third-tier Brentford 4-0 in a fourth-round replay and Manchester City dismissing Leeds United 4-0 in a fifth-round tie.
Third-tier Oldham Athletic have stunned seven-time FA Cup winners Liverpool with a shock 3-2 fourth-round win and Leeds United have caused another big upset by knocking out Tottenham Hotspur 2-1 at Elland Road.
Manchester United are targeting a first FA Cup triumph for nine years after breezing into the last 16 with a 4-1 thrashing of Fulham.
Luton Town have made a mockery of the 85 places between themselves and Norwich City by becoming the first minor league club to beat a top-flight side in the FA Cup for 24 years.
Jack Wilshere's late strike gave Arsenal a 1-0 FA Cup third-round replay win over Swansea City and Manchester United also progressed with a 1-0 victory over West Ham United.
Daniel Sturridge scored on his Liverpool debut and Luis Suarez caused controversy as the seven-time winners beat minor league Mansfield Town 2-1 to reach the FA Cup fourth round.
Chelsea have reached the FA Cup final for the 11th time with a comprehensive, if controversial, 5-1 thrashing of London rivals Tottenham Hotspur at Wembley.
Liverpool strikers Andy Carroll and Luis Suarez put all their troubles behind them to fire their team to a 2-1 win over local rivals Everton in a nerve-jangling FA Cup semifinal at Wembley Stadium.
All Whites captain Ryan Nelsen has scored his first goal for Tottenham in an emotionally charged FA Cup quarterfinal victory over Bolton - a rematch of the tie which was abandoned when Bolton's Fabrice Muamba went into cardiac arrest last Sunday.