Chelsea were embroiled in familiar Premier League high drama as the champions were reduced to 10 men and held 2-2 by Swansea City in an entertaining start to the defence of their title at their home fortress.
Defender Phil Jones has signed a contract extension with Manchester United to keep him at Old Trafford until at least 2019, the Premier League club says.
Chelsea midfielder Cesc Fabregas was sent off in bizarre circumstances as the below-par Premier League champions, playing with 10 men for over an hour, slumped 0-3 at West Bromwich Albion.
Aston Villa were crushed 6-1 by Southampton but joined Leicester City in celebrating Premier League survival, while Steven Gerrard's farewell party was spoiled as Liverpool lost 3-1 to Crystal Palace.
Steven Gerrard spoke of dread, devastation and defeat as the Liverpool captain said farewell to an adoring and emotional Anfield crowd after 17 years and more than 700 appearances.
Arsenal's hopes of catching Manchester City for second place in the Premier League suffered a setback after a late Bafetimbi Gomis header, verified by goalline technology, handed Swansea City a 1-0 win at the Emirates.
Liverpool's hopes of qualifying for the Champions League have all but ended after a 1-1 draw at Premier League title winners Chelsea epitomised a season of shortcomings.
Arsenal all but sealed Champions League qualification for an 18th successive season after they eased past relegation-threatened Hull City 3-1 in the Premier League.
The club anthem Blue is the Colour resounded around a joyful Stamford Bridge and champagne flowed as Chelsea clinched their first Premier League title for five years with a typically stubborn 1-0 victory over Crystal Palace.
Burnley and Queens Park Rangers' Premier League survival hopes were left hanging by a thread after defeats and unfavourable results elsewhere left them rooted to the foot of the table.
The man selling 'Chelsea Champions 2015' scarves outside The Emirates was a little premature but he is unlikely to be asked for refunds after they ground out a 0-0 Premier League draw at Arsenal.
Manchester City ended a difficult week on a high and climbed to within one point of third-placed neighbours Manchester United thanks to a comfortable 2-0 Premier League victory over West Ham United.
Liverpool kept alive their slim hopes of playing Champions League football next season with a 2-0 Premier League home win over Newcastle United who finished with 10 men.
Manchester United put the boot into Manchester City and restored red ascendancy in the city thanks to a crushing 4-2 derby victory at Old Trafford that moved them four points clear of their ailing rivals.
Arsenal's improbable late run at the Premier League title gained further momentum with a 1-0 win over strugglers Burnley, an eighth straight success that moved them four points behind leaders Chelsea.
Crystal Palace left Manchester City's hopes of retaining their Premier League crown in tatters after a 2-1 win at Selhurst Park to leave Manuel Pellegrini's side trailing a distant fourth in the title race.
Liverpool will be without defender Martin Skrtel for three games after he was suspended for a stamp on Manchester United goalkeeper David de Gea during Sunday's Premier League defeat at Anfield.
Juan Mata's marvellous volley helped Manchester United beat Liverpool in the race for Champions League qualification while his former club Chelsea nervously regained their six-point lead in the Premier League.
Manchester City kept their slim title hopes alive thanks to a 3-0 win against 10-man West Bromwich Albion but Arsenal remain hot on their heels after a 2-1 victory against Newcastle United in the Premier League.
Midfielder Jordan Henderson's fluke second-half goal kept Liverpool firmly in contention for a Premier League top-four finish with a 1-0 win at Swansea City.