Foodstuffs and Progressive Enterprises are among opponents calling for a resource consent application to be declined.
A Dunedin City Council planner has recommended the same, and argued granting it would create an undesirable precedent.
The issue will come before a resource consent committee of city councillors Colin Weatherall, Andrew Noone and Richard Walls on Friday.
The application comes from the Invercargill-based C&C Clay Family Trust, through planning consultant Keith Hovell.
A central issue is whether the park would be a retail development in an industrial zoned area, in a city where industrial land is at a premium.
A report to the committee from council planner Kirstyn Lindsay said the application described the development as "a range of industrial, service and commercial activities", at the corner of Orari St and Portsmouth Dr, to be undertaken in three stages.
"The applicant believes that given the uncertain economic climate, it is unlikely that all tenancies can be occupied in the short term."
Because of that, the trust wanted to be able to provide for a mixture of tenants, including everything from liquor, homeware and home entertainment outlets to concrete product and heavy machinery sales.
The seven people or groups making submissions, all of which were opposed, raised unfair competition over more expensive, zone-compliant developments; a lack of clarity on whether it would be retail or wholesale; "commercial creep" into industrial zones and a reduction in available industrial land as reasons to decline the application.
Ms Lindsay said in her report the applicant had not stated whether the general public would be excluded from buying goods from wholesale outlets on the site, but from the plan for the site, activities "are much more likely to be of a retail rather than wholesale nature".
The nature of the plan appeared to be a shopping destination, which would mean a loss of industrial land.
"Overall, I consider that no argument or evidence has been offered to support why commercial and retail activities should be established within this zone over local or central activity zones.
"As such, I consider the loss of industrial land for this purpose to be unacceptable."
Granting the application would weaken the integrity of the district plan, Ms Lindsay said.
Mr Hovell said on Monday the business park would be a combination of industrial and retail.
Asked about the opposition from the supermarket chains, he said from the developer's perspective, they were potential competitors, but also potential business partners, as they could buy wholesale goods from businesses at the park.
