The halfback carries warrior instincts without the same fight for fitness, while the loose forward is a great athlete who cannot find the sting for battle.
Both missed the cut for the Rugby Championship squad as well as an unavailable Rene Ranger and Ben Afeaki, Matt Todd, Francis Saili and Jeremy Thrush, who were involved in the June tests.
Saili, Thrush, Blues wing Frank Halai and prop Joe Moody will train as injury cover each week but then return to their provinces for ITM Cup games.
Weepu survived a lack of form in last year's Super 15 to make the All Blacks and, while his fitness had improved in this campaign, it did not meet the selectors' template.
Vito was a great athlete, coach Steve Hansen said, and needed to play with ''freedom, aggression, intensity and physicality'' but it just had not come.
''So we'd like him to step out and work on his game in the ITM Cup.''
Other All Black loose forwards such as Liam Messam and Jerome Kaino had gone through similar remedial charts.
Weepu's sharpened physique has not kept up with the pace the All Blacks wanted to play and he has been replaced by Thomas TJ Perenara for the tests against the Wallabies, Springboks and Pumas.
Perenara's grandmother and uncle played softball for New Zealand and his father played league for the Junior Kiwis, and the 21-year-old has risen rapidly to the top in rugby.
He captained NZ Secondary Schools in 2010 and debuted for Wellington later that year, played for New Zealand under-20 in 2011 and got his initial Super 15 chance last season.
The selectors have monitored Weepu's work this season, and his 71st and last test start against France in New Plymouth confirmed their opinion.
''We just felt that how we are trying to play the game, the speed of the game we are trying to play, Pow [Weepu] is just struggling with that,'' Hansen said.
''His last game really confirmed what our thoughts were about the speed of his game getting from A to B to C, and because of that his skill set is not flourishing.''
The selectors were not seeing Weepu run or, at times, pass well. He could dictate matches but only if played at his pace.
''He has been an outstanding contributor to New Zealand rugby and his greatest hour was through that World Cup in 2011 when he really stood up and played particularly well,'' Hansen said.
Weepu took a lot of pressure from the young five-eighths Colin Slade and then Aaron Cruden after Dan Carter was injured.
''He [Weepu] has been a great servant to the All Blacks and been an important part of our team for a long time both on and off the field. Like all of us there will be a time when it is time to make the change and the three selectors as a group feel this is the time.''
All Black squad
For the Rugby Championship
Dane Coles, Andrew Hore, Keven Mealamu, Wyatt Crockett, Charlie Faumuina, Ben Franks, Owen Franks, Tony Woodcock, Brodie Retallick, Luke Romano, Samuel Whitelock, Sam Cane, Steven Luatua, Richie McCaw (captain), Liam Messam, Kieran Read, Tawera Kerr-Barlow, TJ Perenara, Aaron Smith, Beauden Barrett, Daniel Carter, Aaron Cruden, Ma'a Nonu, Conrad Smith, Israel Dagg, Charles Piutau, Julian Savea, Ben Smith.
