Two seriously injured people had to be cut free from a vehicle that crashed on the Kaitangata Highway near Balclutha overnight.
Police said a car with four people inside went off the road into a ditch about 1am.
Two of the four had to be cut free from the vehicle and were airlifted to Dunedin Hospital with serious injuries that included possible broken bones, a police spokesman said.
The other two were taken to Clutha Health First in Balclutha for treatment, he said.
Although yet to be confirmed, the spokesman said alcohol may have been a factor in the crash.
Police would continue to investigate, and no charges had been brought at this stage.
