The 25-year-old has been cited for allegedly biting the finger of an Irish player, believed to be Stephen Ferris, during the 30-9 win, the The Telegraph reported.
"England hooker Dylan Hartley has been cited following the RBS 6 Nations match between England and Ireland at Twickenham on Saturday for an alleged biting offence,'' a Six Nations statement said.
"The independent Six Nations citing commissioner for the match, Alberto Recaldini (Italy), cited the England player under IRB Law 10.4(m), 'Acts contrary to good sportsmanship', for allegedly biting the finger of an opponent in the 23rd minute of the first half.
"The player's hearing will be held by an independent Six Nations disciplinary committee at a date to be confirmed.''
If banned, Hartley could be ruled out of England's three-test tour to South Africa which begins on June 9.
In 2007, Hartley was banned for six months after eye-gouging three separate opponents when playing for Northampton against London Wasps.