Mandy Hurst, Jude O’Connor, Julie Livesey and Denise Davidson depart from Te Paki on Sunday and will finish their hike at Kohukohu.
In between they will walk along the beach, through the bush and into small settlements like Hukatere, Ahipara, Herkino and Broadwood.
All in their 60s, the quartet will be joined by other walkers, mountain bikers and horse riders and will follow a well marked route.
A large support crew of volunteers will be on hand.
Many of the places they will pass through are off the tourist path and will offer a unique taste of New Zealand’s landscapes and scenery.
The outdoor adventure is organised by charitable trust Trek For Life Aotearoa/NZ which aims to support and empower local communities. Funds raised will be given to first response and rescue services operating in those communities.
Mandy Hurst said the four friends were excited and up for the trekking challenge.
They were all fit for their age and looking forward to checking out the unspoilt beauty and sparsely populated towns of the Far North.
She said day two was the big walking day on the trek, and the 44km distance lined up was "a bit of a daunting prospect".
Mrs Hurst said the quartet would use trekking poles to help take the pressure off knees and joints.
Two had elected to splash out for the VIP two-person dorm tent at night, while the others would be in a 10-person tent.
"We’ll be able to grab a shower every night, and even though it will be far from ‘glamping’, we’ll be well looked after."
She said at the end of a long day of walking a glass of wine would taste better and be well deserved.